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Linifanib(ABT-869)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Linifanib(ABT-869)图片
CAS NO:796967-16-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
ABT869, ABT-869
产品介绍

生物活性

Linifanib (ABT-869)是一种结构新颖的有效RTK,VEGF和PDGF抑制剂,对人内皮细胞,PDGFR-β,KDR和CSF-1R的IC50分别为0.2、2、4和7 nM。

Targets

TargetValue
VEGFR1/FLT1IC50: 3nM
CSF-1RIC50: 3nM
VEGFR2/KDRIC50: 4nM
FLT3IC50: 4nM
KitIC50: 14nM
PDGFRβIC50: 66nM
Tie-2IC50: 170nM
VEGFR3/FLT4IC50: 190nM
SGKIC50: 940nM
RETIC50: 1.9μM
PKAIC50: 5.9μM
Cdc2IC50: 9.8μM
FGFRIC50: >12.5μM
LynIC50: >20μM
LCKIC50: 38μM
SrcIC50: >50μM
IGFRIC50: >50μM
INSRIC50: >50μM
EGFRIC50: >50μM
HckIC50: >50μM
c-MetIC50: >50μM
FynIC50: >50μM
FGRIC50: >50μM
AktIC50: >50μM

化学数据

目录号A10025
作用机制Inhibitor (抑制剂)
M. Wt375.4
FormulaC21H18FN5O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.796967-16-3
SynonymsABT869, ABT-869
SMILESCC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N

溶解度

In vitro (25°C)DMSO73 mg/mL (194.45 mM)
WaterInsoluble
EthanolInsoluble
In vivo5%DMSO+40%PEG 300+5%Tween80+50%ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM26.64 mL133.19 mL266.38 mL
0.5 mM5.33 mL26.64 mL53.28 mL
1 mM2.66 mL13.32 mL26.64 mL
5 mM0.53 mL2.66 mL5.33 mL

*The above data is based on the productmolecular weight 375.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.