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AEE788
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AEE788图片
CAS NO:497839-62-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
AEE-788, NVP-AEE788
产品介绍

生物活性

AEE788是一种口服生物可用的多受体酪氨酸激酶抑制剂,可抑制EGFR,HER2和VEGF2酪氨酸激酶的磷酸化。

Targets

TargetValue
EGFRIC50: 2nM
HER2/ErbB2IC50: 6nM
c-AblIC50: 52nM
FLT1IC50: 59nM
c-FmsIC50: 60nM
c-SrcIC50: 61nM
KDRIC50: 77nM
HER4/ErbB4IC50: 160nM
PDGFRβIC50: 320nM
FLT4IC50: 330nM
FLT3IC50: 730nM
RETIC50: 740nM
c-KitIC50: 790nM
TekIC50: 2.1μM
C-Raf-1IC50: 2.8μM
c-MetIC50: 2.9μM
CDK1/CyclinBIC50: 8.0μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
PKCαIC50: >10μM
PKAIC50: >10μM

化学数据

目录号A10043
作用机制Inhibitor (抑制剂)
M. Wt440.6
FormulaC27H32N6
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.497839-62-0
SynonymsAEE-788, NVP-AEE788
SMILESCCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4N[C@H](C)C5=CC=CC=C5

溶解度

In vitro (25°C)DMSO81 mg/mL (183.84 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.7 mL113.48 mL226.96 mL
0.5 mM4.54 mL22.7 mL45.39 mL
1 mM2.27 mL11.35 mL22.7 mL
5 mM0.45 mL2.27 mL4.54 mL

*The above data is based on the productmolecular weight 440.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.