生物活性
AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck，Lyn，Btk，Syk和Src无活性的JAK2。
靶点信息
| EGFR (Cell-free assay) | JAK2 (Cell-free assay) | ErbB2 (Cell-free assay) | | |
| 0.1 μM | ~10 μM | 13.5 μM | | |
化学数据
| 目录号 | A10047 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 294.3 |
| Formula | C17H14N2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 133550-30-8 |
| Synonyms | Tyrphostin AG490 |
| SMILES | C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N |
溶解度
| In vitro (25°C) | DMSO | 54 mg/mL (183.48 mM) |
| Water | Insoluble |
| Ethanol | 6 mg/mL |
| In vivo | 5% DMSO+40% PEG300+5% Tween80+50% ddH2O | 5.93 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 33.98 mL | 169.89 mL | 339.79 mL |
| 0.5 mM | 6.8 mL | 33.98 mL | 67.96 mL |
| 1 mM | 3.4 mL | 16.99 mL | 33.98 mL |
| 5 mM | 0.68 mL | 3.4 mL | 6.8 mL |
*The above data is based on the productmolecular weight 294.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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