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AG-490
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AG-490图片
CAS NO:133550-30-8
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
Tyrphostin AG490
产品介绍

生物活性

AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck,Lyn,Btk,Syk和Src无活性的JAK2。

靶点信息

EGFR (Cell-free assay)JAK2 (Cell-free assay)ErbB2 (Cell-free assay)
0.1 μM~10 μM13.5 μM

化学数据

目录号A10047
作用机制Inhibitor (抑制剂)
M. Wt294.3
FormulaC17H14N2O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.133550-30-8
SynonymsTyrphostin AG490
SMILESC1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

溶解度

In vitro (25°C)DMSO54 mg/mL (183.48 mM)
WaterInsoluble
Ethanol6 mg/mL
In vivo5% DMSO+40% PEG300+5% Tween80+50% ddH2O5.93 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM33.98 mL169.89 mL339.79 mL
0.5 mM6.8 mL33.98 mL67.96 mL
1 mM3.4 mL16.99 mL33.98 mL
5 mM0.68 mL3.4 mL6.8 mL

*The above data is based on the productmolecular weight 294.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.