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AP24534(Ponatinib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AP24534(Ponatinib)图片
CAS NO:943319-70-8
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
Ponatinib
产品介绍

生物活性

AP24534 (Ponatinib)是有效的多激酶和pan-BCR-ABL抑制剂。

Targets

TargetValue
AblIC50: 0.37nM
PDGFRαIC50: 1.1nM
VEGFR2IC50: 1.5nM
FGFR1IC50: 2.2nM
c-SrcIC50: 5.4nM
c-KitIC50: 12.5nM
Insulin ReceptorIC50: >1μM
IGF-1RIC50: >1μM
AuroraAIC50: >1μM
CDK2/CyclinEIC50: >1μM

化学数据

目录号A10080
作用机制Inhibitor (抑制剂)
M. Wt532.6
FormulaC29H27F3N6O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.943319-70-8
SynonymsPonatinib
SMILESCC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

溶解度

In vitro (25°C)DMSO30 mg/mL (56.33 mM)
WaterInsoluble
EthanolInsoluble
In vivo1% CMC Na28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.78 mL93.88 mL187.76 mL
0.5 mM3.76 mL18.78 mL37.55 mL
1 mM1.88 mL9.39 mL18.78 mL
5 mM0.38 mL1.88 mL3.76 mL

*The above data is based on the productmolecular weight 532.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.