生物活性
AS703026 (Pimasertib)是一种新型的,选择性的,口服可生物利用的MEK1/2抑制剂,可抑制MM细胞的生长和存活以及细胞因子诱导的破骨细胞分化。
化学数据
目录号 | A10089 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 431.2 |
Formula | C15H15FIN3O3 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 1236699-92-5 |
Synonyms | AS-703026, MSC1936369B |
SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NC[C@@H](CO)O |
溶解度
In vitro (25°C) | DMSO | 78 mg/mL (180.89 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 0.5% CMC+0.25% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 23.19 mL | 115.96 mL | 231.91 mL |
0.5 mM | 4.64 mL | 23.19 mL | 46.38 mL |
1 mM | 2.32 mL | 11.6 mL | 23.19 mL |
5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
*The above data is based on the productmolecular weight 431.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.