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Asenapine Maleate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Asenapine Maleate图片
CAS NO:85650-56-2
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

Asenapine maleate平对多种受体具有高亲和力(pKi),包括5-羟色胺5-HT1A(8.6),5-HT1B(8.4),5-HT2A(10.2),5-HT2B(9.8),5-HT2C(10.5),5 -HT5A(8.8),5-HT6(9.5)和5-HT7(9.9)受体,肾上腺素α1(8.9),α2A(8.9),α2B(9.5)和α2C(8.9)受体,多巴胺D1( 8.9),D2(8.9),D3(9.4)和D4(9.0)受体以及组胺H1(9.0)和H2(8.2)受体。

Targets

TargetValue
5-HT2Cpki: 10.46
5-HT2Apki: 10.15
5-HT7pki: 9.94
5-HT2Bpki: 9.75
5-HT6pki: 9.6
α2B-adrenergicreceptorpki: 9.49
D3receptorpki: 9.38
H1receptorpki: 9
D4receptorpki: 8.95
α1A-adrenergicreceptorpki: 8.93
α2C-adrenergicreceptorpki: 8.91
D2LReceptorpki: 8.9
α2A-adrenergicreceptorpki: 8.9
D1receptorpki: 8.85
5-HT5Apki: 8.84
D2SReceptorpki: 8.84
5-HT1Apki: 8.6
5-HT1Bpki: 8.4
H2receptorpki: 8.21

化学数据

目录号A10091
作用机制Antagonist (拮抗剂)
M. Wt401.84
FormulaC17H16ClNO.C4H4O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.85650-56-2
SMILESCN1C[C@H]2[C@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O

溶解度

In vitroDMSO78 mg/mL (194.1 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM24.89 mL124.43 mL248.86 mL
0.5 mM4.98 mL24.89 mL49.77 mL
1 mM2.49 mL12.44 mL24.89 mL
5 mM0.5 mL2.49 mL4.98 mL

*The above data is based on the productmolecular weight 401.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.