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AT7519
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AT7519图片
CAS NO:844442-38-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
AT-7519
产品介绍

生物活性

AT7519是多种细胞周期蛋白依赖性激酶(CDK)的抑制剂,可导致细胞周期停滞,诱导细胞凋亡和抑制肿瘤细胞增殖。作用于CDK1,2,4,6和9时,IC50为10-210 nM,对CDK3作用效果稍弱,对CDK7几乎没有抑制活性。

Targets

TargetValue
CDK9/CyclinTIC50:<10nM
CDK5/p35IC50: 13nM
CDK2/CyclinAIC50: 47nM
GSK-3βIC50: 89nM
CDK4/CyclinD1IC50: 100nM
CDK6/CyclinD3IC50: 170nM
CDK1/CyclinBIC50: 210nM
CDK3/CyclinEIC50: 360nM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
TrkBIC50: >1μM
JAK2IC50: >1μM
CDK7/CyclinH/MAT1IC50: 2.4μM
SAPK2A(p38α)IC50: >10μM
p70S6KIC50: >10μM
PDGFRIC50: >10μM
PDK-1IC50: >10μM
PKBβIC50: >10μM
VEGFR1IC50: >10μM
AuroraAIC50: >10μM
c-AblIC50: >10μM
c-SrcIC50: >10μM
Chk1IC50: >10μM
EGFRIC50: >10μM
FGFR3IC50: >10μM
IRIC50: >10μM
JNK2IC50: >10μM
MAPK1IC50: >10μM
MEK1IC50: >10μM
MetIC50: >10μM

化学数据

目录号A10093
作用机制Inhibitor (抑制剂)
M. Wt382.2
FormulaC16H17Cl2N5O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.844442-38-2
SynonymsAT-7519
SMILESC1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl

溶解度

In vitro (25°C)DMSO9 mg/mL (23.54 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+30% PEG 300+2% Tween 80+ddH2O1 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM26.16 mL130.82 mL261.64 mL
0.5 mM5.23 mL26.16 mL52.33 mL
1 mM2.62 mL13.08 mL26.16 mL
5 mM0.52 mL2.62 mL5.23 mL

*The above data is based on the productmolecular weight 382.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.