Apoptosis inducer;antioxidant;flavonoid
CAS：520-18-3
分子式：C15H10O6
分子量：286.24
纯度：98%
存储：Store at -20°C

Background:

IC50: N/A

Kaempferol, a phytoestrogen and one of the most common dietary flavonoids, is widely distributed in tea, broccoli, gingko biloba, onions, grapes, apples, medicinal herbs and other plant sources. Growing evidences have indicated that Kae has antioxidative and anti-inflammatory properties.

In vitro: Previous studies demonstrated that kaempferol was able to reduce LPS-challenged TNF-α and IL-1β expression in activated macrophages and also inhibited the TNF-α-induced translocation of NF-κB subunit p65 to the nucleus and the secretion of IL-6 and monocyte chemoattractant protein-1 (MCP-1) [1].

In vivo: BALB/c mice with ALI, induced by intranasal instillation of LPS, were treated with kaempferol 1 h prior to LPS exposure. Kaempferol treatment attenuated pulmonary edema of mice with ALI after LPS challenge, as shown bu the fact that it markedly decreased the lung W/D ratio, protein concentration and the amounts of inflammatory cells in BALF. Similarly, LPS mediated overproduction of proinflammatory cytokines in BALF was reduced by kaempferol strongly. Histological studies demonstrated kaempferol inhibited LPS-induced alveolar hemorrhage, alveolar wall thickness and leukocytes infiltration in lung with evidence of reduced myeloperoxidase activity substantially. Kaempferol also efficiently increased superoxide dismutase activity in lung when compared with LPS group,which was obviously reduced by LPS administration [1].

Clinical trial: N/A

Reference:
[1] Chen X,Yang X,Liu T,Guan M,Feng X,Dong W,Chu X,Liu J,Tian X,Ci X,Li H,Wei J,Deng Y,Deng X,Chi G,Sun Z.  Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice. Int Immunopharmacol.2012 Oct;14(2):209-16.