Background:

RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors. 5-HT1A, 5-HT1B[1]

RU 24969 (0.03-3.0 mg/kg; s.c.; 15 minutes) dose-dependently decreases water consumption in water deprived rats[3]. Animal Model: Male Sprague-Dawley rats (water bottles were removed for 23.75 hours) [3]

[1]. Doods HN, et al. Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity. Eur J Pharmacol. 1985 Jun 19;112(3):363-70. [2]. Green AR, et al. The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants. Neuropharmacology. 1984 Jun;23(6):655-61. [3]. Aronsen D, et al. RU 24969-produced adipsia and hyperlocomotion: Differential role of 5HT1A and 5HT1B receptor mechanisms. Pharmacol Biochem Behav. 2014 May 15;124C:1-4. [4]. Cheetham SC, et al. Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1B receptor. Br J Pharmacol. 1993 Dec;110(4):1621-9.