您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > BI6727(Volasertib)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
BI6727(Volasertib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BI6727(Volasertib)图片
CAS NO:755038-65-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
Volasertib, BI-6727
产品介绍

生物活性

BI6727 (Volasertib)是一种高效且选择性的polo样激酶(PLK)1抑制剂(在一组癌细胞系中,酶IC50 = 0.87 nM,EC50 = 11-37 nM)。

靶点信息

PLK1 (Cell-free assay)
0.87 nM

化学数据

目录号A10135
作用机制Inhibitor (抑制剂)
M. Wt618.8
FormulaC34H50N8O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.755038-65-4
SynonymsVolasertib, BI-6727
SMILESCC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C

溶解度

In vitro (25°C)DMSOWarmed: 19 mg/mL (30.7 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+corn oil1 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM16.16 mL80.8 mL161.6 mL
0.5 mM3.23 mL16.16 mL32.32 mL
1 mM1.62 mL8.08 mL16.16 mL
5 mM0.32 mL1.62 mL3.23 mL

*The above data is based on the productmolecular weight 618.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.