您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > BIBR 953(Dabigatran,Pradaxa)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
BIBR 953(Dabigatran,Pradaxa)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIBR 953(Dabigatran,Pradaxa)图片
CAS NO:211914-51-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
BIBR-953, BIBR953
产品介绍

生物活性

BIBR 953 (Dabigatran,Pradaxa)是一种高度选择性,可逆且有效的凝血酶抑制剂,可作为前药达比加群酯口服。它在血栓形成的动物模型中显示出抗血栓形成的功效,起效迅速,可预测的药效学反应。

靶点信息

Thrombin (Cell-free assay)
9.3 nM

化学数据

目录号A10138
作用机制Inhibitor (抑制剂)
M. Wt471.5
FormulaC25H25N7O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.211914-51-1
SynonymsBIBR-953, BIBR953
SMILESCN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N

溶解度

In vitro (25°C)DMSO<1 mg/mL
Water29 mg/mL (61.5 mM)
Ethanol0.01 mg/mL (0.02 mM)
In vivo10% Trifluoroacetic acid water solution31 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.21 mL106.04 mL212.09 mL
0.5 mM4.24 mL21.21 mL42.42 mL
1 mM2.12 mL10.6 mL21.21 mL
5 mM0.42 mL2.12 mL4.24 mL

*The above data is based on the productmolecular weight 471.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.