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BIBW2992(Afatinib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIBW2992(Afatinib)图片
CAS NO:439081-18-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
Tomtovok,Afatinib
产品介绍

生物活性

BIBW2992 (Afatinib)是酪氨酸激酶抑制剂(TKI),它不可逆地抑制人表皮生长因子受体2(Her2)和表皮生长因子受体(EGFR)激酶。

靶点信息

EGFR (L858R) (Cell-free assay)EGFR (wt) (Cell-free assay)EGFR (L858R/T790M) (Cell-free assay)HER2 (Cell-free assay)
0.4 nM0.5 nM10 nM14 nM

化学数据

目录号A10141
作用机制Inhibitor (抑制剂)
M. Wt485.9
FormulaC24H25ClFN5O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.439081-18-2
SynonymsTomtovok,Afatinib
SMILESCN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.58 mL102.9 mL205.8 mL
0.5 mM4.12 mL20.58 mL41.16 mL
1 mM2.06 mL10.29 mL20.58 mL
5 mM0.41 mL2.06 mL4.12 mL

*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.