您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > BIIB021
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
BIIB021
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIIB021图片
CAS NO:848695-25-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
CNF2024
产品介绍

生物活性

BIIB021是一种口服全合成Hsp90抑制剂,可选择性和有效地抑制分子伴侣Hsp90。

靶点信息

HSP90HSP90
1.7 nM(Ki)38 nM(EC50)

化学数据

目录号A10143
作用机制Inhibitor (抑制剂)
M. Wt318.8
FormulaC14H15ClN6O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.848695-25-0
SynonymsCNF2024
SMILESCC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N

溶解度

In vitro (25°C)DMSO60 mg/mL (188.22 mM)
WaterInsoluble
Ethanol2 mg/mL (6.27 mM)
In vivo30% propylene glycol, 5% Tween 80, 65% D5W28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM31.37 mL156.84 mL313.68 mL
0.5 mM6.27 mL31.37 mL62.74 mL
1 mM3.14 mL15.68 mL31.37 mL
5 mM0.63 mL3.14 mL6.27 mL

*The above data is based on the productmolecular weight 318.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.