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PD184352(CI-1040)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PD184352(CI-1040)图片
CAS NO:212631-79-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
CI-1040
产品介绍

生物活性

PD184352 (CI-1040)是一种ATP非竞争性MEK1/2抑制剂,在基于细胞的测定中,IC50为17 nM,对MEK1/2的选择性是对MEK5的100倍。

靶点信息

MEK1 (Cell-free assay)MEK2 (Cell-free assay)
17 nM17 nM

化学数据

目录号A10212
作用机制Inhibitor (抑制剂)
M. Wt478.7
FormulaC17H14ClF2IN2O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.212631-79-3
SynonymsCI-1040
SMILESC1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl

溶解度

In vitro (25°C)DMSO92 mg/mL (192.19 mM)
WaterInsoluble
Ethanol13 mg/mL (27.15 mM)
In vivo30% PEG400+0.5% Tween80+5% propylene glycol, pH 99 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.89 mL104.45 mL208.9 mL
0.5 mM4.18 mL20.89 mL41.78 mL
1 mM2.09 mL10.44 mL20.89 mL
5 mM0.42 mL2.09 mL4.18 mL

*The above data is based on the productmolecular weight 478.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.