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CUDC-101
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CUDC-101图片
CAS NO:1012054-59-9
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
CUDC101
产品介绍

生物活性

CUDC-101是一种抑制多种靶标的新型化合物,旨在抑制HDAC,EGFR和Her2。

Targets

TargetValue
EGFRIC50: 2.4nM
HDACIC50: 4.4nM
HDAC1IC50: 4.5nM
HDAC6IC50: 5.1nM
HDAC3IC50: 9.1nM
HDAC5IC50: 11.4nM
HDAC2IC50: 12.6nM
HDAC4IC50: 13.2nM
HER2IC50: 15.7nM
HDAC10IC50: 26.1nM
HDAC9IC50: 67.2nM
HDAC8IC50: 79.8nM
HDAC7IC50: 373nM

化学数据

目录号A10246
作用机制Inhibitor (抑制剂)
M. Wt434.5
FormulaC24H26N4O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1012054-59-9
SynonymsCUDC101
SMILESCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO

溶解度

In vitro (25°C)DMSO20 mg/mL (46.03 mM)
WaterInsoluble
EthanolInsoluble
In vivo15% Captisol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.01 mL115.07 mL230.15 mL
0.5 mM4.6 mL23.01 mL46.03 mL
1 mM2.3 mL11.51 mL23.01 mL
5 mM0.46 mL2.3 mL4.6 mL

*The above data is based on the productmolecular weight 434.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.