生物活性
Docetaxel (Taxotere)多西他赛一种taxol类似物，是一种microtubules解聚抑制剂，通过结合于稳定的微管发挥作用。
靶点信息
| Microtubules (Cell-free assay) | | | | |
| | | | |
化学数据
| 目录号 | A10326 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 807.9 |
| Formula | C43H53NO14 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 114977-28-5 |
| Synonyms | Taxotere |
| SMILES | CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O |
溶解度
| In vitro (25°C) | DMSO | 92 mg/mL (113.88 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 49 mg/mL (60.65 mM) |
| In vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O | 1 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 12.38 mL | 61.89 mL | 123.78 mL |
| 0.5 mM | 2.48 mL | 12.38 mL | 24.76 mL |
| 1 mM | 1.24 mL | 6.19 mL | 12.38 mL |
| 5 mM | 0.25 mL | 1.24 mL | 2.48 mL |
*The above data is based on the productmolecular weight 807.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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