生物活性
Fasudil HCl (HA-1077)是一种环状核苷酸依赖性蛋白激酶抑制剂和Rho相关激酶抑制剂（IC50 = 10.7μM）。
靶点信息
| ROCK2 (Cell-free assay) | PKA (Cell-free assay) | PKG (Cell-free assay) | PKC (Cell-free assay) | MLCK (Cell-free assay) |
| 330 nM(Ki) | 1.6 μM(Ki) | 1.6 μM(Ki) | 3.3 μM(Ki) | 36 μM(Ki) |
化学数据
| 目录号 | A10381 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 327.8 |
| Formula | C14H17N3O2S.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 105628-07-7 |
| Synonyms | AT-877 |
| SMILES | C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl |
溶解度
| In vitro (25°C) | DMSO | 5 mg/mL (15.25 mM) |
| Water | 60 mg/mL (183.02 mM) |
| Ethanol | Insoluble |
| In vivo | Saline | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 30.51 mL | 152.53 mL | 305.06 mL |
| 0.5 mM | 6.1 mL | 30.51 mL | 61.01 mL |
| 1 mM | 3.05 mL | 15.25 mL | 30.51 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.1 mL |
*The above data is based on the productmolecular weight 327.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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