Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.
CAS:128914-47-6
分子式:C20H32O3
分子量:320.5
纯度:98%
存储:Store at -20°C
Background:
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 µM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.