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GDC-0941(Pictilisib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GDC-0941(Pictilisib)图片
CAS NO:957054-30-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
GDC0941
产品介绍

生物活性

GDC-0941 (Pictilisib)是一种强效、选择性、口服生物可利用的I类PI3激酶(PI3K)抑制剂,p110 α、β、δ和γ亚型、DNA-PK和mTOR的IC50值分别为3、33、3、75、1230和580 nM。

Targets

TargetValue
p110αIC50: 3nM
p110δIC50: 3nM
p110βIC50: 33nM
p110γIC50: 75nM
mTORKiapp0.58μM
C2βIC50: 0.67μM
DNA-PKIC50: 1.23μM
Vps34IC50: >10μM

化学数据

目录号A10421
作用机制Inhibitor (抑制剂)
M. Wt513.6
FormulaC23H27N7O3S2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.957054-30-7
SynonymsGDC0941
SMILESCS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6

溶解度

In vitro (25°C)DMSO40 mg/mL (77.87 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+30% PEG 300+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.47 mL97.35 mL194.7 mL
0.5 mM3.89 mL19.47 mL38.94 mL
1 mM1.95 mL9.74 mL19.47 mL
5 mM0.39 mL1.95 mL3.89 mL

*The above data is based on the productmolecular weight 513.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.