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Gefitinib(Iressa)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gefitinib(Iressa)图片
CAS NO:184475-35-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
10mM * 1mL in DMSO电议

产品名称
ZD-1839
产品介绍

生物活性

Gefitinib (Iressa)是一种EGFR抑制剂,可阻断靶细胞中表皮生长因子受体(EGFR)的信号传导。

靶点信息

Tyr1173 (NR6W cells)Tyr1173 (NR6wtEGFR cells)Tyr992 (NR6wtEGFR cells)Tyr992 (NR6W cells)
26 nM37 nM37 nM57 nM

化学数据

目录号A10422
作用机制Inhibitor (抑制剂)
M. Wt446.9
FormulaC22H24ClFN4O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.184475-35-2
SynonymsZD-1839
SMILESCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

溶解度

In vitro (25°C)DMSO80 mg/mL (179 mM)
WaterInsoluble
Ethanol4 mg/mL (8.95 mM)
In vivo1% CMC Na28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.38 mL111.88 mL223.76 mL
0.5 mM4.48 mL22.38 mL44.75 mL
1 mM2.24 mL11.19 mL22.38 mL
5 mM0.45 mL2.24 mL4.48 mL

*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.