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GSK461364
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK461364图片
CAS NO:929095-18-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品名称
GSK 461364, GSK-461364
产品介绍

生物活性

GSK461364 是polo样激酶1 (Plk1)的ATP竞争性抑制剂。

靶点信息

PLK1 (Cell-free assay)
2.2 nM(Ki)

化学数据

目录号A10442
作用机制Inhibitor (抑制剂)
M. Wt543.6
FormulaC27H28F3N5O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.929095-18-1
SynonymsGSK 461364, GSK-461364
SMILESC[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N

溶解度

In vitro (25°C)DMSO9 mg/mL (16.55 mM)
WaterInsoluble
Ethanol27 mg/mL (49.66 mM)
In vivo1% DMSO+30% polyethylene glycol+1% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.4 mL91.98 mL183.96 mL
0.5 mM3.68 mL18.4 mL36.79 mL
1 mM1.84 mL9.2 mL18.4 mL
5 mM0.37 mL1.84 mL3.68 mL

*The above data is based on the productmolecular weight 543.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.