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Saridegib(IPI-926)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Saridegib(IPI-926)图片
CAS NO:1037210-93-7
规格:98%
分子量:504.77
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Saridegib是Smo的特异性有效抑制剂,这是Hedgehog通路中关键的跨膜信号蛋白。
CAS:1037210-93-7
分子式:C29H48N2O3S
分子量:504.77
纯度:98%
存储:Store at -20°C

Background:

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.



Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model[1].


[1]. Ko AH, et al. A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. Pancreas. 2016 Mar;45(3):370-5.