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D-3263
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D-3263图片
CAS NO:947257-66-1
规格:98%
分子量:373.49
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
D-3263是一种有效的TRPM8激动剂,具有抗肿瘤活性。
CAS:947257-66-1
分子式:C21H31N3O3
分子量:373.49
纯度:98%
存储:Store at -20°C

Background:

D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.


D-3263 induces calcium flux and cell death in in vitro cells expressing TRPM8[1].


D-3263 (50 or 100 mg/kg/d) alone or with Finasteride (10 mg/kg/d) results in reduction in prostate hyperplasia of rats with evidence of a dose response. The highest dose of the TRPM8 agonist D-3263, given in combination with Finasteride, results in lower prostate weights than the highest dose of D-3263 or Finasteride given alone, suggesting a potential additive effect[1].


[1]. David Duncan, et al. PRECLINICAL EVALUATION OF THE TRPM8 ION CHANNEL AGONIST D-3263 FOR BENIGN PROSTATIC HYPERPLASIA. THE JOURNAL OF UROLOGY, Vol. 181, No. 4, Supplement, Tuesday, April 28, 2009