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GNE 220
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GNE 220图片
CAS NO:1199590-75-4
规格:98%
分子量:438.53
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
GNE-220是一种有效的选择性MAP4K4抑制剂,IC50为7nM。
CAS:1199590-75-4
分子式:C25H26N8
分子量:438.53
纯度:98%
存储:Store at -20°C

Background:

GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.


GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs)[1].



[1]. Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519(7544):425-30.