生物活性
Honokiol是存在于广玉兰的球果、树皮和叶子中的木脂素，在黑色素瘤、肉瘤、骨髓瘤、白血病、膀胱、肺、前列腺、口腔鳞状细胞癌和结肠癌细胞系中显示促凋亡作用。
靶点信息
化学数据
| 目录号 | A10453 |
| M. Wt | 266.3 |
| Formula | C18H18O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 35354-74-6 |
| Synonyms | houpa, hnk |
| SMILES | C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C |
溶解度
| In vitro (25°C) | DMSO | 52 mg/mL (195.24 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 1 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 37.55 mL | 187.76 mL | 375.52 mL |
| 0.5 mM | 7.51 mL | 37.55 mL | 75.1 mL |
| 1 mM | 3.76 mL | 18.78 mL | 37.55 mL |
| 5 mM | 0.75 mL | 3.76 mL | 7.51 mL |
*The above data is based on the productmolecular weight 266.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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