| CAS NO: | 62284-79-1 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 373.22 |
|---|---|
| Formula | C13H13BrN2O4S |
| CAS No. | 62284-79-1 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 74 mg/mL (198.3 mM) |
| Water: 30 mg/mL (80.4 mM) | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: (S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate InChi Key: ZULBIBHDIQCNIS-HNCPQSOCSA-N InChi Code: InChI=1S/C11H11BrN2S.C2H2O4/c12-9-3-1-8(2-4-9)10-7-14-5-6-15-11(14)13-10;3-1(4)2(5)6/h1-4,10H,5-7H2;(H,3,4)(H,5,6)/t10-;/m1./s1 SMILES Code: BrC1=CC=C([C@H]2CN3C(SCC3)=N2)C=C1.OC(C(O)=O)=O |
| Synonyms | L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate; (-)-p-Bromolevamisole oxalate; L-p-Bromotetramisole Oxalate |
| In Vitro | In vitro activity: (-)-p-Bromotetramisole Oxalate is an inhibitor of alkaline phosphatase and protein tyrosine phosphatases. In various rat tissues, (-)-p-Bromotetramisole Oxalate (0.1 μM) completely inhibited non-specific alkaline phosphatase. In rat zona glomerulosa, (-)-p-Bromotetramisole Oxalate (100 μM) blocked the inhibition of Na+ pump (Na+, K+-ATPase) induced by angiotensin II. The result suggested that inhibition of the Na+ pump induced by angiotensin II might be mediated by a tyrosine phosphatase. In neurosecretory PC12 cells, (-)-p-Bromotetramisole Oxalate (0.3 mM) increased ionomycin-stimulated noradrenaline (NA) release, which suggested that tyrosine phosphorylation regulated Ca2+-stimulated NA release. |
|---|---|
| In Vivo | In Sprague-Dawley rats, (-)-p-Bromotetramisole Oxalate (10 μM) significantly increased fractional excretion of phosphate (FEPi) from 4.7% to 13.4%. |
| Animal model | Rats |
| Formulation & Dosage | 10 μM |
| References | Histochemistry, 1975, 44(3): 277-280; Eur J Pharmacol, 2000, 406(1): 49-52; Proc Soc Exp Biol Med, 1996, 213(2): 193-195. |
m.cnreagent.com