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AC480(BMS-599626)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AC480(BMS-599626)图片
CAS NO:714971-09-2
规格:98%
分子量:567.01
包装与价格:
包装价格(元)
5mg电议
25mg电议
100mg电议

产品介绍
HER1/2 inhibitor,selective and efficacious
CAS:714971-09-2
分子式:C27H27FN8O3.HCl
分子量:567.01
纯度:98%
存储:Store at -20°C

Background:

AC480 (BMS-599626) is a potent, selective inhibitor of human epidermal growth factor receptor (HER) that inhibits HER1 and HER2 with IC values of 20 nM and 30 nM, respectively. AC480 has been proved to inhibit HER1 in an ATP-competitive?manner. On the contrary, AC480 has shown to be an ATP noncompetitive inhibitor of HER2 [1]


AC480 inhibited the proliferation of Sal2 cells derived from a transgenic mouse tumor, breast tumor and gastric carcinoma cell lines, GEO colon tumor cells, non–small-cell lung tumor cells line via HER1 and/or HER2 signalings [1].


AC480 by oral administration has been demonstrated to suppress the?growth of Sal2 tumor, GEO xenograft tumor, KPL-4 and BT474 breast tumors, N87 gastric tumor, A549 and L2987 non–small-cell lung tumors in nude mice [1].


参考文献:
[1] Wong TW1,?Lee FY,?Yu C,?Luo FR,?Oppenheimer S,?Zhang H,?Smykla RA,?Mastalerz H,?Fink BE,?Hunt JT,Gavai AV,?Vite GD. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res.?2006 Oct 15;12(20 Pt 1):6186-93.