您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Solutol HS-15
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Solutol HS-15
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Solutol HS-15图片
CAS NO:61909-81-7
规格:98%
包装与价格:
包装价格(元)
5g电议
10g电议
50g电议

产品介绍

SolutolHS-15是一种通透性增强剂。
CAS:61909-81-7
分子式:(C2H4O)nC18H36O3
分子量:
纯度:98%
存储:Store at -20°C

Background:

Solutol HS-15 is a permeability enhancer.

Solutol HS-15 is a permeability enhancer. A general decline in cell metabolic activity is seen for all three tested cell lines as the concentration of Solutol HS-15 solution is increased. Results demonstrate that Solutol HS-15 promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Solutol HS-15, relative to the respective control, at 4°C. Solutol HS-15 treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control)[1].

参考文献
[1]. Shubber S, et al. Mechanism of mucosal permeability enhancement of CriticalSorb? (Solutol? HS15) investigated in vitro in cell cultures. Pharm Res. 2015 Feb;32(2):516-27.