CAS NO: | 61909-81-7 |
规格: | 98% |
包装 | 价格(元) |
5g | 电议 |
10g | 电议 |
50g | 电议 |
SolutolHS-15是一种通透性增强剂。
CAS:61909-81-7
分子式:(C2H4O)nC18H36O3
分子量:
纯度:98%
存储:Store at -20°C
Background:
Solutol HS-15 is a permeability enhancer.
Solutol HS-15 is a permeability enhancer. A general decline in cell metabolic activity is seen for all three tested cell lines as the concentration of Solutol HS-15 solution is increased. Results demonstrate that Solutol HS-15 promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Solutol HS-15, relative to the respective control, at 4°C. Solutol HS-15 treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control)[1].
参考文献
[1]. Shubber S, et al. Mechanism of mucosal permeability enhancement of CriticalSorb? (Solutol? HS15) investigated in vitro in cell cultures. Pharm Res. 2015 Feb;32(2):516-27.