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Maribavir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Maribavir图片
CAS NO:176161-24-3
包装:1mg
规格:98%
市场价:1376元
分子量:376.24

产品介绍
UL97 or pUL97 inhibitor
CAS:176161-24-3
分子式:C15H19Cl2N3O4
分子量:376.24
纯度:98%
存储:Store at -20°C

Background:

Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC50 of 3 nM. Maribavir has potent antiviral activity against HCMV and Epstein-Barr virus (EBV).


Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC50 of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC50 of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (