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Risperidone hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Risperidone hydrochloride图片
CAS NO:666179-74-4
规格:98%
分子量:446.95
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Risperidone hydrochloride 是 5-HT2 的阻断剂和多巴胺 D2 受体的有效拮抗剂,其 Ki 值分别为0.16,1.4 nM。
CAS:666179-74-4
分子式:C23H28ClFN4O2
分子量:446.95
纯度:98%
存储:Store at -20°C

Background:

Risperidone hydrochloride is a serotonin 5-HT2 receptor blocker and a potent dopamine D2 receptor antagonist, with Kis of 0.16, 1.4 nM for 5-HT2 and D2 receptor, respectively. 5-HT2 Receptor|0.16 nM (Ki)|D2 receptor|1.4 nM (Ki)


Risperidone is serotonin 5-HT2 receptor blocker as shown by displacement of radioligand binding (Ki=0.16 nM), activity on isolated tissues (EC50=0.5 nM). Risperidone is also a potent dopamine D2 receptor antagonist as indicated by displacement of radioligand binding (Ki=1.4 nM), activity in isolated striatal slices (IC50=0.89 nM)[1]. Risperidone increases the production of IL-10 and MDC as well as the proinflammatory cytokines, such as IL-6, IL-8, and TNF-α, but decreases the production of IP-10 and IL-12[2].


Long-Evans rats receive daily subcutaneous injections of vehicle or 1 of 2 doses of risperidone (1.0 and 3.0 mg/kg per day) from postnatal Days 14 to 42. Weight gain during development is slightly yet significantly reduced in risperidone-treated rats. In the first 2 experiments, early-life Risperidone administration is associated with increased locomotor activity at 1 week post administration through approximately 9 months of age, independent of changes in weight gain[2].


[1]. Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cellapoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12(1):197-204. [2]. Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21(3):259-67.