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ML115
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML115图片
CAS NO:912798-42-6
规格:98%
分子量:322.7
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.
CAS:912798-42-6
分子式:C15H15ClN2O4
分子量:322.7
纯度:98%
存储:Store at -20°C

Background:

Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.