Sordarin is an inhibitor of fungal protein synthesis originally isolated from S.
CAS：463356-00-5
分子式：C27H39O8.Na
分子量：514.6
纯度：98%
存储：Store at -20°C

Background:

Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa. It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml). It inhibits the growth of C. albicans (MIC = 8 μg/ml) but not C. glabrata or C. neoformans (MICs = >125 μg/ml).