Donitriptan 是一种有效的高亲和力 5-HT1B/1D 受体激动剂,pKi 分别为 9.4 和 9.3。
CAS:170912-52-4
分子式:C23H25N5O2
分子量:403.48
纯度:98%
存储:Store at -20°C
Background:
Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1].
5-HT1B Receptor|9.4 (pKi)|5-HT1D Receptor|9.3 (pKi)
[1]. MuÑoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91.