Argipressin可与血管精氨酸加压素受体V1结合，其在A7r5大鼠主动脉平滑肌细胞中的Kd值为1.31nM。
CAS：113-79-1
分子式：C46H65N15O12S2
分子量：1084.23
纯度：98%
存储：Store at -20°C

Background:

Argipressin binds to the V1-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells.

Argipressin binds to the vascular arginine vasopressin receptor, V1, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells. It also stimulates the intracellular release of calcium in A7r5 cells (EC50=5 nM)[1]. AVP-induced [Ca2+]i signals and immunized activity against S-100 in DRG cell culture. The minimum effective concentrations of Argipressin causing [Ca2+]i responses are 100 pM in non-neuronal cells in DRG culture[2].

[1]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56. [2]. Moriya T, et al. Vasopressin-induced intracellular Ca²? concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12.