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Lapatinib Ditosylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lapatinib Ditosylate图片
CAS NO:388082-77-7
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

Lapatinib是一种双重酪氨酸激酶抑制剂,可阻断HER2生长受体途径。

Targets

TargetValue
ErbB2IC50: 9.2nM
EGFRIC50: 10.8nM
ErbB4IC50: 367nM
c-SrcIC50: 3.5μM
C-Raf-1IC50: >10μM
MEKIC50: >10μM
ERKIC50: >10μM
c-FmsIC50: >10μM
CDK1IC50: >10μM
CDK2IC50: >10μM
p38IC50: >10μM
Tie-2IC50: >10μM
VEGFR2IC50: >10μM

化学数据

目录号A10514
作用机制Inhibitor (抑制剂)
M. Wt925.46
FormulaC43H42ClFN4O10S3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.388082-77-7
SMILESCC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

溶解度

In vitro (25°C)DMSO93 mg/mL (100.49 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+30% PEG 300+ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM10.81 mL54.03 mL108.05 mL
0.5 mM2.16 mL10.81 mL21.61 mL
1 mM1.08 mL5.4 mL10.81 mL
5 mM0.22 mL1.08 mL2.16 mL

*The above data is based on the productmolecular weight 925.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.