CAS NO: | 1246094-78-9 |
规格: | ≥98% |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Name: AZD7762 HCl CAS#: 1246094-78-9 (HCl salt); Chemical Formula: C17H20ClFN4O2S Exact Mass: 398.098Molecular Weight: 398.88 | |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Technical Information | Synonym: AZD-7762 Hydrochloride; AZD-7762 HCl; AZD7762; AZD 7762; AZD-7762. Chemical Name: (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide Hydrochloride InChi Key: WFZBLOIXZRZEDG-YDALLXLXSA-N InChi Code: InChI=1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1 SMILES Code: O=C(C1=C(NC(N)=O)C=C(C2=CC=CC(F)=C2)S1)N[C@@H]3CNCCC3.[H]Cl |
AZD7762 HCl (AZD-7762) is a novel, potent, selective, ATP-competitive, and synthetic small molecule checkpoint kinase (Chk) inhibitor with anticancer activity. It has an IC50 of 5 nM for Chk1. AZD-7762 has potential chemosensitizing activity by binding to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.
References: Oncotarget. 2016 Aug 2;7(31):49800-49818.; Mol Cancer Ther. 2008 Sep;7(9):2955-66.