MM-589 is a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM (Ki <1 nM) and inhibits the MLL H3K4 methyltransferase (HMT) activity with an IC50 of 12.7 nM. MM-589 potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations and is >40 times better than the previously reported compound MM-401. MM-589 represents the most potent inhibitor of the WDR5–MLL interaction reported to date, and further optimization of MM-589 may yield a new therapy for acute leukemia. References:

纯度：≥98%

CAS：2097887-21-1