生物活性
LY335979 (Zosuquidar trihydrochloride)是一种强效高选择性P-gp抑制剂。
靶点信息
| P-gp (Cell-free assay) | | | | |
| 60 nM(Ki) | | | | |
化学数据
| 目录号 | A10549 |
| 作用机制 | Modulator (调节剂) |
| M. Wt | 637.0 |
| Formula | C32H31F2N3O2.3HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 167465-36-3 |
| Synonyms | LY-335979, Zosuquidar trihydrochloride,RS-33295-198 |
| SMILES | C1CN(CCN1C[C@H](COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5[C@H]6[C@H](C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl |
溶解度
| In vitro (25°C) | DMSO | 93 mg/mL (145.99 mM) |
| Water | 21 mg/mL (32.96 mM) |
| Ethanol | Insoluble |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 15.7 mL | 78.49 mL | 156.99 mL |
| 0.5 mM | 3.14 mL | 15.7 mL | 31.4 mL |
| 1 mM | 1.57 mL | 7.85 mL | 15.7 mL |
| 5 mM | 0.31 mL | 1.57 mL | 3.14 mL |
*The above data is based on the productmolecular weight 637.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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