生物活性
Metolazone和其他噻嗪类利尿剂可抑制氯化钠转运体的功能，并防止钠和氯化物以及水离开管腔进入小管细胞。
靶点信息
化学数据
| 目录号 | A10584 |
| M. Wt | 365.8 |
| Formula | C16H16ClN3O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 17560-51-9 |
| Synonyms | Zaroxolyn, Mykrox, Zytanix |
| SMILES | CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl |
溶解度
| In vitro | DMSO | 68 mg/mL (185.87 mM) |
| Water | Insoluble |
| Ethanol | 7 mg/mL (19.13 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 27.34 mL | 136.69 mL | 273.37 mL |
| 0.5 mM | 5.47 mL | 27.34 mL | 54.67 mL |
| 1 mM | 2.73 mL | 13.67 mL | 27.34 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.47 mL |
*The above data is based on the productmolecular weight 365.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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