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MLN8054
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MLN8054图片
CAS NO:869363-13-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
MLN-8054
产品介绍

生物活性

MLN8054是一种有效的,选择性Aurora A抑制剂,在Sf9昆虫细胞中IC50为4 nM,作用于Aurora A比作用于Aurora B选择性高40倍,可在体内和体外诱导人肿瘤细胞衰老。

Targets

TargetValue
AuroraAIC50: 4nM
AuroraBIC50: 172nM
LCKIC50: 3.2μM
PKAIC50: 19μM
CK2IC50: 20.5μM
Chk2IC50: 28μM
PLK1IC50: 53μM
Chk1IC50: >100μM
PKCIC50: >100μM
CaMKIIIC50: >100μM
CDK2EIC50: >100μM
CDK1IC50: >100μM

化学数据

目录号A10601
作用机制Inhibitor (抑制剂)
M. Wt476.9
FormulaC25H15ClF2N4O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.869363-13-3
SynonymsMLN-8054
SMILESC1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O

溶解度

In vitro (25°C)DMSO91 mg/mL (190.82 mM)
WaterInsoluble
EthanolInsoluble
In vivo15% Captisol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.97 mL104.84 mL209.69 mL
0.5 mM4.19 mL20.97 mL41.94 mL
1 mM2.1 mL10.48 mL20.97 mL
5 mM0.42 mL2.1 mL4.19 mL

*The above data is based on the productmolecular weight 476.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.