生物活性
MLN9708是一种蛋白酶体抑制剂，可抑制蛋白酶体的活性，从而阻断通常由蛋白酶体进行的靶向蛋白水解。
靶点信息
| 20S proteasome (Cell-free assay) | 20S proteasome (Cell-free assay) | | | |
| 0.93 nM(Ki) | 3.4 nM | | | |
化学数据
| 目录号 | A10602 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 517.1 |
| Formula | C20H23BCl2N2O9 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1201902-80-8 |
| Synonyms | MLN-9708 |
| SMILES | B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)[C@H](CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl |
溶解度
| In vitro (25°C) | DMSO | 85 mg/mL (164.36 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 0.5% hydroxyethyl cellulose | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.34 mL | 96.69 mL | 193.39 mL |
| 0.5 mM | 3.87 mL | 19.34 mL | 38.68 mL |
| 1 mM | 1.93 mL | 9.67 mL | 19.34 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.87 mL |
*The above data is based on the productmolecular weight 517.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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