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Mubritinib(TAK 165)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mubritinib(TAK 165)图片
CAS NO:366017-09-6
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
TAK-165, TAK165
产品介绍

生物活性

Mubritinib (TAK 165)是一种有效的EGFR和p34cdc2抑制剂,IC50分别为6 nM和0.2 ?M。Mubritinib(TAK 165)也抑制p33cdk2和p33cdk5。

Targets

TargetValue
HER2/ErbB2IC50: 6.0nM
EGFRIC50: >25μM
FGFRIC50: >25μM
PDGFRIC50: >25μM
JAK1IC50: >25μM
SrcIC50: >25μM
BLKIC50: >25μM

化学数据

目录号A10612
作用机制Inhibitor (抑制剂)
M. Wt468.5
FormulaC25H23F3N4O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.366017-09-6
SynonymsTAK-165, TAK165
SMILESC1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)/C=C/C4=CC=C(C=C4)C(F)(F)F

溶解度

In vitro (25°C)DMSO12 mg/mL (25.61 mM)
WaterInsoluble
EthanolInsoluble
In vivo1% DMSO+30% polyethylene glycol+1% Tween 804 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.34 mL106.72 mL213.45 mL
0.5 mM4.27 mL21.34 mL42.69 mL
1 mM2.13 mL10.67 mL21.34 mL
5 mM0.43 mL2.13 mL4.27 mL

*The above data is based on the productmolecular weight 468.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.