生物活性
Myricetin (Cannabiscetin)是一种具有抗氧化和抗肿瘤活性的天然黄酮，是新型的MEK1抑制剂，抑制JB6 P+小鼠表皮细胞的转化。它还能抑制PI3Kγ，Kd=0.17 μM。
靶点信息
化学数据
| 目录号 | A10615 |
| M. Wt | 318.2 |
| Formula | C15H10O8 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 529-44-2 |
| Synonyms | Cannabiscetin, Myricetol, Myricitin |
| SMILES | C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O |
溶解度
| In vitro (25°C) | DMSO | 59 mg/mL (185.39 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 8 mg/mL (25.14 mM) |
| In vivo | 4% DMSO+30% PEG 300+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 31.43 mL | 157.13 mL | 314.27 mL |
| 0.5 mM | 6.29 mL | 31.43 mL | 62.85 mL |
| 1 mM | 3.14 mL | 15.71 mL | 31.43 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.29 mL |
*The above data is based on the productmolecular weight 318.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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