生物活性
Nelarabine是一种嘌呤核苷类似物，可转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸（araGTP），从而抑制DNA合成和细胞毒性，IC50为0.067-2.15 μM。
靶点信息
| DNA synthesis (PER-255 cells) | DNA synthesis (HSB2 cells) | DNA synthesis (ALL-SIL cells) | DNA synthesis (JURKAT cells) | |
| 67 nM | 0.44 μM | 1.24 μM | 2.15 μM | |
化学数据
| 目录号 | A10632 |
| M. Wt | 297.3 |
| Formula | C11H15N5O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 121032-29-9 |
| Synonyms | 506U78 |
| SMILES | COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N |
溶解度
| In vitro (25°C) | DMSO | 55 mg/mL (185.01 mM) |
| Water | 3 mg/mL (10.09 mM) |
| Ethanol | Insoluble |
| In vivo | saline | 2 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 33.64 mL | 168.18 mL | 336.36 mL |
| 0.5 mM | 6.73 mL | 33.64 mL | 67.27 mL |
| 1 mM | 3.36 mL | 16.82 mL | 33.64 mL |
| 5 mM | 0.67 mL | 3.36 mL | 6.73 mL |
*The above data is based on the productmolecular weight 297.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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