生物活性
Nilotinib (AMN-107)是一种Bcr-Abl抑制剂，IC50小于30 nM。
靶点信息
| Bcr-Abl (Murine myeloid progenitor cells) | | | | |
| <30 nM | | | | |
化学数据
| 目录号 | A10644 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 529.5 |
| Formula | C28H22F3N7O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 641571-10-0 |
| Synonyms | AMN107 |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5 |
溶解度
| In vitro (25°C) | DMSO | 26 mg/mL (49.09 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 4% DMSO+30% PEG 300+5% Tween 80+ddH2O | 2 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 18.89 mL | 94.43 mL | 188.86 mL |
| 0.5 mM | 3.78 mL | 18.89 mL | 37.77 mL |
| 1 mM | 1.89 mL | 9.44 mL | 18.89 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
*The above data is based on the productmolecular weight 529.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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