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Nutlin-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nutlin-3图片
CAS NO:548472-68-0
包装与价格:
包装价格(元)
5mg电议
25mg电议
50mg电议
100mg电议

产品名称
Nutlin3
产品介绍

生物活性

Nutlin-3是一种有效的,选择性Mdm2(它自身和p53的环指依赖性泛素蛋白连接酶)拮抗剂,是有效的凋亡诱导剂。

化学数据

目录号A10657
作用机制Antagonist (拮抗剂)
M. Wt581.5
FormulaC30H30Cl2N4O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.548472-68-0
SynonymsNutlin3
SMILESCC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

溶解度

In vitroDMSO87 mg/mL (149.61 mM)
WaterInsoluble
Ethanol26 mg/mL (44.71 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.2 mL85.98 mL171.97 mL
0.5 mM3.44 mL17.2 mL34.39 mL
1 mM1.72 mL8.6 mL17.2 mL
5 mM0.34 mL1.72 mL3.44 mL

*The above data is based on the productmolecular weight 581.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.