生物活性
TAE684是ALK的抑制剂，也是LRRK2激酶活性的有效抑制剂（针对野生型LRRK2的IC（50）为7.8nM，针对G2019S突变体的为6.1nM）。
靶点信息
| ALK (Cell-free assay) | | | | |
| 3 nM | | | | |
化学数据
| 目录号 | A10662 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 614.2 |
| Formula | C30H40ClN7O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 761439-42-3 |
| Synonyms | NVP-TAE684 , TAE-684 |
| SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC |
溶解度
| In vitro (25°C) | DMSO | 3 mg/mL (4.88 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol, pH 4 | 9 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 16.28 mL | 81.41 mL | 162.81 mL |
| 0.5 mM | 3.26 mL | 16.28 mL | 32.56 mL |
| 1 mM | 1.63 mL | 8.14 mL | 16.28 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.26 mL |
*The above data is based on the productmolecular weight 614.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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