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MN-64
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MN-64图片
CAS NO:92831-11-3
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
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25mg电议
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1g电议

产品介绍

MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system. Tankyrases are ADP-ribosyltransferases that play key roles in various cellular pathways, including the regulation of cell proliferation, and thus, they are promising drug targets for the treatment of cancer. References: Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtio L. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9. doi: 10.1021/jm401463y. Epub 2013 Oct 11. PubMed PMID: 24116873.

纯度:≥98%

CAS:92831-11-3