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PF-2341066(Crizotinib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-2341066(Crizotinib)图片
CAS NO:877399-52-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
PF02341066
产品介绍

生物活性

PF-2341066 (Crizotinib)是c-Met激酶和NPM-ALK的抑制剂。PF-2341066抑制ALK阳性ALCL细胞中的细胞增殖(IC50 = 30 nM)。

靶点信息

c-Met (A549, MDA-MB-231, GTL-16, HT29, 786-O, Colo-205, A498 cells)ALK (Karpas299 cells)
11 nM24 nM

化学数据

目录号A10712
作用机制Inhibitor (抑制剂)
M. Wt450.3
FormulaC21H22Cl2FN5O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.877399-52-5
SynonymsPF02341066
SMILESC[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

溶解度

In vitro (25°C)DMSO8 mg/mL (17.76 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+30% PEG 300+dd H2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.21 mL111.04 mL222.07 mL
0.5 mM4.44 mL22.21 mL44.41 mL
1 mM2.22 mL11.1 mL22.21 mL
5 mM0.44 mL2.22 mL4.44 mL

*The above data is based on the productmolecular weight 450.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.