您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > PHA-793887
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PHA-793887
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PHA-793887图片
CAS NO:718630-59-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
PHA793887
产品介绍

生物活性

PHA-793887是一种新型有效的CDK2,CDK5和CDK7抑制剂,IC50分别为8 nM,5 nM 和10 nM,作用于CDK2,5,和7比作用于CDK1,4,和9选择性高6倍以上。可在低浓度下靶向多种细胞周期蛋白依赖性激酶,并具有针对多种癌细胞的高活性。

Targets

TargetValue
CDK5/p25IC50: 5nM
CDK2/CyclinAIC50: 8nM
CDK2/CyclinEIC50: 8nM
CDK7/CyclinHIC50: 10nM
CDK1/CyclinBIC50: 60nM
CDK4/CyclinD1IC50: 62nM
GSK-3βIC50: 79nM
CDK9/CyclinT1IC50: 138nM

化学数据

目录号A10716
作用机制Inhibitor (抑制剂)
M. Wt361.5
FormulaC19H31N5O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.718630-59-2
SynonymsPHA793887
SMILESCC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C

溶解度

In vitro (25°C)DMSO61 mg/mL (168.75 mM)
WaterInsoluble
Ethanol61 mg/mL (168.75 mM)
In vivo30% propylene glycol, 5% Tween 80, 65% D5W14 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM27.66 mL138.31 mL276.63 mL
0.5 mM5.53 mL27.66 mL55.33 mL
1 mM2.77 mL13.83 mL27.66 mL
5 mM0.55 mL2.77 mL5.53 mL

*The above data is based on the productmolecular weight 361.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.